Clinical Outcomes of Lamivudine Therapy and HLA Alleles in Chronic Hepatitis B Patients.
- Author:
Ji Min OH
1
;
Kyu Heum KWON
;
Jang Eon KIM
;
Jin Ho CHOI
;
Sun Hee BEOM
;
Sang Hyuk LEE
;
Yong Jik LEE
;
Mi Young PARK
;
Mee Kyung JUNG
;
Kye Heui LEE
Author Information
1. Department of Internal Medicine, Seoul Medical Center, Seoul, Korea. people@chol.com
- Publication Type:Original Article ; English Abstract
- Keywords:
HLA;
Hepatitis B virus (HBV);
Lamivudine
- From:The Korean Journal of Gastroenterology
2008;52(6):368-375
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The human leukocyte antigen (HLA) system is an integral component of immune response. Highly polymorphic HLA genes may play a pivotal role in the response of antiviral therapy. We investigated the effects of HLA gene polymorphism on the clinical outcome of chronic hepatitis B patients who received lamivudine treatment. METHODS: Depending on their clinical response to lamivudine therapy, a total of sixty one patients were divided into following groups; non-responders, viral breakthroughers, relapsers, and seroconverters. HLA-A, -B, -Cw, -DRB and HLA-DRB1 alleles typing was performed on each group through the polymerase chain reaction and the sequence-specific oligonucleotide hybridization method. The distribution patterns of HLA-A, HLA-B, HLA-Cw, HLA-DRB, and HLA-DRB1 were then analysed. RESULTS: When non-responders were compared to the other groups, high frequencies in HLA-Cw*1, HLA-DRB1*4 and HLA-DRB*4 (p=0.015, 0.033 and 0.004 respectively) were evident. When seroconverters were compared to viral breakthroughers, high frequencies in HLA-A*2 and HLA-DRB*4 (p=0.048, 0.025 respectively) were evident. CONCLUSIONS: Our data suggests that HLA-A*2, HLA-Cw*1, HLA-DRB1*4 genes are related to the clinical outcomes of lamivudine treatment in chronic hepatitis B patients. These genes may be used in the prediction of the clinical outcome of lamivudine therapy in chronic hepatitis B patients.
