Effects of Cryosurgery in Primary Lung Cancer.
- Author:
Won Jae JUNG
1
;
Kwang Taik KIM
;
Eun Jue YI
;
Sung Ho LEE
;
Moon Chul KANG
;
Jae Ho CHUNG
;
Soo Yeoun HAM
;
Sung Bum JO
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Korea Ansan Hospital, Korea University College of Medicine, Korea.
- Publication Type:Original Article
- Keywords:
Lung;
Lung neoplasms;
Cryosurgery
- MeSH:
Cryosurgery;
Disease Progression;
Female;
Fever;
Humans;
Length of Stay;
Lung;
Lung Neoplasms;
Male;
Positron-Emission Tomography;
Retrospective Studies;
Sputum;
Subcutaneous Emphysema;
Thorax
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2009;42(2):201-205
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Cryosurgery has been used to treat primary malignant pulmonary tumors at our institute since November 2004. In this study we analyzed our treatment results and complication rates. MATERIAL AND METHOD: A retrospective study using medical charts and imaging data was conducted involving 17 patients with a total of 17 malignant pulmonary tumors who were treated between November 2004 and March 2007. Fourteen patients were males and 3 were females. The median age of the patients was 64 years (range, 54~77 years). The average size of the tumors was 48.8 mm (range, 36~111 mm) in diameter. The patients were followed with chest CT scans 7 days, 1 month, 3 months, and 6 months postoperatively. PET scans were obtained between 6 and 9 months postoperatively. The treatment response was analyzed according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria. RESULT: Six months after treatment, 6 tumors (35.3%) showed a complete response, 4 (23.5%) had a partial response, 3 (17.6%) had stable disease, and 4 (23.5%) showed disease progression. In tumors <4 cm in diameter, a complete response was reported in 50% of the tumors. A chi-square-test showed that in tumors <4 cm in diameter, the p-value for results better than a partial response was 0.034. With respect to procedural complications, there was 1 case of blood-tinged sputum which resolved spontaneously within 1 or 2 days, a spontaneously relieved case of subcutaneous emphysema, and 1 patient with a fever. There were no mortalities and the average hospital stay was 6.3 days. CONCLUSION: The effects of cryosurgery on primary lung cancer is greatest in patients with small tumors. Considering the facts that cryosurgery is minimally invasive, has a low complication rate, and can be performed repetitively, we believe that it may play an important role in the treatment of high risk lung cancer patients.
