Comparison of Outcomes after Curative Resection of Primary Lung Cancer between 50 Year or Younger and 70 Year or Older Patients.
- Author:
Jae Ik LEE
1
;
Keun Woo KIM
;
Kook Yang PARK
;
Chul Hyun PARK
;
Yang Bin JEON
;
Chang Hyu CHOI
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Hospital, Korea. pittz@hanmail.net
- Publication Type:Original Article
- Keywords:
Lung neoplasms;
Age;
Outcome assessment;
Survival rate;
Recurrence
- MeSH:
Carcinoma, Non-Small-Cell Lung;
Comorbidity;
Follow-Up Studies;
Freedom;
Humans;
Lung;
Lung Neoplasms;
Medical Records;
Neoplasm Staging;
Prognosis;
Recurrence;
Survival Rate
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2009;42(2):206-213
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Previous series have suggested that younger patients with primary lung cancer exhibit a more aggressive disease course with a worse prognosis, as compared to older patients, although this issue is still debatable. MATERIAL AND METHOD: We reviewed the medical records of 79 patients (32 patients 50 years and younger (Group I) and 47 patients 70 years and older (Group II)) who underwent curative resection for primary lung cancer between July 2000 and June 2008. RESULT: The median age of the patients was 46.5 years in Group I and this was 73 years in Group II. The older patients were more likely to have major comorbidities (44% versus 77%, respectively; p=0.003). Histological examinations identified that the minor histological types (excluding non-small cell lung cancer (NSCLC)) were predominantly found in the Group I patients (16% versus 2%, respectively; p=0.037). For the TNM staging of the NSCLC, with excluding the minor histologic types, a higher proportion of patients had stage III disease in Group I (33% versus 13%, respectively; p=0.038). There was no significant difference in major morbidity (16% versus 30%, respectively; p=0.148) and operative mortality (0% versus 4.3%; p=0.512) between the groups. The mean follow-up interval was 33 months (range: 1~98 months) for patients in both groups. For the patients with NSCLC, the five-year overall survival rate was 52.3% for Group I and 53.7% for Group II (p=0.955). The rate of freedom from recurrence at five years was significantly lower for the Group I patients than for the Group II patients (39.4% versus 70.4%, respectively; p=0.027), and only being a member of Group I impacted recurrence, based on the Cox proportional hazard analysis (p=0.034). Of the patients who had recurrence, four patients in Group I underwent aggressive surgical treatment. All of these patients exhibited long-term survival (range: 46~87 months). CONCLUSION: In our study, the early outcome and long-term survival were similar for the younger and older patients after curative resection of primary lung cancer. However, we think that younger patients require meticulous follow-up as they had a tendency to proceed to surgery with advanced stage disease, a higher recurrence rate than did the older patients and the survival rates were improved, even for the recurred cases, with early aggressive treatment.
