Association of Hepatic Iron Deposition and Serum Iron Indices with Hepatic Inflammation and Fibrosis Stage in Nonalcoholic Fatty Liver Disease.
- Author:
Joon Ho MOON
1
;
Sang Hoon PARK
;
Kil Chan OH
;
Jae One JUNG
;
Woon Geon SHIN
;
Jong Pyo KIM
;
Kyoung Oh KIM
;
Cheol Hee PARK
;
Taeho HAHN
;
Kyo Sang YOO
;
Jong Hyeok KIM
;
Dong Jun KIM
;
Myung Seok LEE
;
Choong Kee PARK
;
Sun Young JUN
Author Information
1. Department of Internal Medicine, Hallym University College of Medicine, Anyang, Korea. sanghoon@hallym.or.kr
- Publication Type:Original Article ; English Abstract
- Keywords:
Nonalcoholic fatty liver disease;
Iron;
Liver damage
- MeSH:
Adolescent;
Adult;
Fatty Liver/complications/*metabolism;
Female;
Ferritins/blood;
Humans;
Inflammation;
Iron/blood/*metabolism;
Liver/*metabolism/pathology;
Liver Cirrhosis/*etiology/metabolism/pathology;
Male;
Middle Aged
- From:The Korean Journal of Gastroenterology
2006;47(6):432-439
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Nonalcoholic steatohepatitis can develop from nonalcoholic fatty liver and progress to severe liver disease such as cirrhosis. The mechanism determining the progression from fatty liver to steatohepatitis is unknown. Iron is suspected to enhance hepatic damage associated with nonalcoholic fatty liver disease (NAFLD). The aims of this study were to evaluate the relationship of serum iron indices and hepatic iron deposition with hepatic fibrosis or inflammation, and to assess whether the increased hepatic iron deposition is an independent predictor of progression to liver injury. METHODS: The biochemical and histopathological data of thirty-nine patients with NAFLD were analyzed. Liver biopsy findings were graded according to the method described by Brunt, et al. Hepatic iron concentration was available in 29 of 39 patients. RESULTS: The mean hepatic iron concentration and hepatic iron indices were 1,349+/-1,188 microgram/g dry weight and 0.9+/-0.7 microgram/g/age. Serum ferritin and body mass indices were associated with hepatic inflammation (p=0.001, p=0.006) and fibrosis (p=0.005, p=0.013). Hepatic iron concentration and hepatic iron index were not associated with hepatic inflammation and fibrosis. Multivariate analysis did not identify serum ferritin or body mass index as an independent predictor of liver injury. CONCLUSIONS: Hepatic iron deposition shows no association with the degree of hepatic inflammation or fibrosis. Hepatic iron is not an independent predictor of hepatic injury in patients with NAFLD.
