Association of the CYP1B1 Gene Polymorphism with the Risk of Advanced Endometriosis in Korean Women.
- Author:
Yeon Jean CHO
;
Sung Eun HUR
;
Ji Young LEE
;
In Ok SONG
;
Mi Kyoung KOONG
;
Hye Sung MOON
;
Hye Won CHUNG
- Publication Type:Original Article
- Keywords:
Endometriosis;
CYP1B1;
Genetic polymorphism
- MeSH:
Endometriosis*;
Female;
Genotype;
Humans;
Odds Ratio;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Polymorphism, Restriction Fragment Length
- From:Korean Journal of Fertility and Sterility
2006;33(2):85-95
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To investigate whether polymorphisms of gene encoding CYP1B1 is associated with the risk of endometriosis in Korean women. METHODS: We investigated 199 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 183 control group women who were surgically proven to have no endometriosis. The genetic distribution of four different CYP1B1 polymorphisms at G119-T, G432-C, T449-C, and A453-G were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products. RESULTS: We found no overall association between each individual CYP1B1 genotype and the risk of endometriosis. The odds ratio of genotype GG/GC+GG/TC+TT/AA compared to GG/CC/CC/AA (reference) was calculated as 2.06 with a 95% confidence interval of 1.003~4.216. CONCLUSIONS: This results suggest that CYP1B1 genetic polymorphism may be associated with development of endometriosis in Korean women.
