Diagnosis and Treatment Modalities in Pseudomyxoma Peritonei.
- Author:
Yeong Jin LEE
1
;
Hee Cheol KIM
;
Dong Hee LEE
;
Chang Sik YU
;
Jin Cheon KIM
Author Information
1. Colorectal Clinic, Asan Medical Center, Korea. hckim@www.amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Pseudomyxoma peritonei;
CEA;
Computerized tomography
- MeSH:
Abdominal Pain;
Appendix;
Biopsy;
Carcinoembryonic Antigen;
Colon;
Cystadenoma;
Diagnosis*;
Drug Therapy;
Female;
Fluorouracil;
Gelatin;
Humans;
Mucins;
Omentum;
Ovary;
Physical Examination;
Prognosis;
Pseudomyxoma Peritonei*;
Retrospective Studies;
Survival Rate;
Ultrasonography
- From:Journal of the Korean Society of Coloproctology
2001;17(3):130-134
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pseudomyxoma peritonei is an unusual condition in which gelatinous fluid collection is associated with mucinous implants on the peritoneal surfaces and omentum. PURPOSE: The aim of this study was to evaluate the clinical characteristics of pseudomyxoma peritonei and elucidate the optimal treatment modality. METHODS: Nine patients (male: female=2: 7) who had been operated on due to pseudomyxoma peritonei were analyzed retrospectively, in terms of clinical characteristics. RESULTS: The common symptoms and signs were abdominal pain, mass and distension. Elevated serum carcinoembryonic antigen (CEA) level was found in six cases. CT and ultrasonography were most valid diagnostic tools for pseudomyxoma peritonei. Six cases underwent debulking operation as initial treatment and two of them underwent intraoperative chemotherapy with 5-fluorouracil and other three cases did open biopsy. The origin of the primary tumor were appendix in three cases, ovary and appendix in three cases, ovary and colon in one case, ovary in one case, while the tumor origin could not be identified in one case. The three cases with cystadenoma remain free of disease after debulking operation. 2-Year survival rate of nine cases was 75%. CONCLUSIONS: This study suggested that (1) the preoperative diagnosis could be made with careful physical examination in conjunction with sonography or computerized tomography; (2) the prognosis may be better in patient with benign origin and aggressive surgical management; (3) serum CEA level may be valuable for detection of this disease.
