A Case of Recurrent Cervical Cancer Responded to Paclitaxel and Carboplatin Combination.
- Author:
Hyun Hoon CHUNG
;
Jae Weon KIM
;
Moon Hong KIM
;
Joo Won NO
;
Noh Hyun PARK
;
Yong Sang SONG
;
Soon Beom KANG
;
Hyo Pyo LEE
;
Seong Il KIM
;
Taek Sang LEE
- Publication Type:Case Report
- Keywords:
recurrent cervical cancer;
paclitaxel-carboplatin
- MeSH:
Carboplatin*;
Carcinoma, Squamous Cell;
Cervix Uteri;
Drug Therapy;
Female;
Granulocyte Colony-Stimulating Factor;
Humans;
Hysterectomy;
Infusions, Intravenous;
Lung;
Paclitaxel*;
Uterine Cervical Neoplasms*
- From:Korean Journal of Gynecologic Oncology and Colposcopy
2000;11(3):336-342
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report the case of a patient with a recurrent squamous cell carcinoma of the cervix, FIGO stage IIa, that metastasized to both lung fields 5 years after primary radical hysterectomy and adjuvant pelvic irradiation. The tumor was resistant to UFT-cisplatin regimen. We used a combination of paclitaxel (175mg/m2 intravenous infusion over 3 hours) and carboplatin with a target area under the curve of 4.5 microgram-h/ml and repeated every 3 weeks. The patient well tolerated the chemotherapy with minor neurologic side effect and myelosuppression controlled by granulocyte colony-stimulating factor. The disease went into remission. Thus, the combination of paclitaxel and carboplatin may be a good combination in recurrent or advanced squamous cell carcinoma of the cervix.
