Hepatitis G virus infection in hemodialysis and continuous ambulatory peritoneal dialysis patients.
10.3349/ymj.1998.39.2.116
- Author:
Hyunjin NOH
1
;
Shin Wook KANG
;
Seung Hyuk CHOI
;
Sug Kyun SHIN
;
Bo Jeung SEO
;
In Hee LEE
;
Kyu Hun CHOI
;
Dae Suk HAN
;
Hyon Suk KIM
;
Ho Yung LEE
Author Information
1. Department of Internal Medicine, Institute of Kidney Disease, Yonsei University College of Medicine, Seoul, Korea. noh@medikorea.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Hepatitis G virus;
hemodialysis;
CAPD
- MeSH:
Female;
Hepatitis Agents, GB*/genetics;
Hepatitis C/genetics;
Hepatitis C-Like Viruses/genetics;
Hepatitis, Viral, Human/virology;
Hepatitis, Viral, Human/genetics;
Hepatitis, Viral, Human/etiology*;
Human;
Male;
Middle Age;
Peritoneal Dialysis, Continuous Ambulatory/adverse effects*;
Prevalence;
RNA, Viral/analysis;
Renal Dialysis/adverse effects*;
Viremia/genetics
- From:Yonsei Medical Journal
1998;39(2):116-121
- CountryRepublic of Korea
- Language:English
-
Abstract:
To determine the prevalence and clinical relevance of HGV infection in dialysis patients, we performed a cross-sectional study of 61 HD patients and 79 Continuous Ambulatory Peritoneal Dialysis (CAPD) patients. HGV-RNA was identified by reverse-transcription (RT) polymerase chain reaction (PCR) assay with primers from the 5'-untranslated region of the viral genome. The prevalence of HGV infection was similar in HD and CAPD patients (9.8% vs. 12.7%), while that of HCV infection was significantly higher in HD patients compared to CAPD patients (16.4% vs. 1.3%, p < 0.05). The mean age (49.2 +/- 13.4 vs. 46.7 +/- 13.0 years), male to female ratio (2.4:1 vs. 1.3:1), history of transfusion (62.3% vs. 49.4%), history of hepatitis (27.9% vs. 26.6%), mean ALT level during the previous 6 months (22.4 +/- 37.9 vs. 14.0 +/- 7.4 IU/L), and the prevalence of HBsAg (8.2% vs. 6.3%) showed no difference between HD and CAPD patients. In both HD and CAPD patients, the presence of HGV RNA was not related to age, sex, duration of dialysis, history of transfusion, history of hepatitis, or to the presence of HBV or HCV markers. There was no significant difference in the clinical and biochemical data between patients with isolated HGV infection (n = 12) and patients without viremia (n = 106). The clinical feature of patients coinfected with HGV and HBV (n = 2), or HGV and HCV (n = 2) seemed to be similar to those of patients with isolated HBV (n = 8) or HCV (n = 9) infection. In conclusion, the prevalence of HGV infection was not different between HD and CAPD patients, and HGV infections did not seem to be associated with clinically significant hepatitis. The routes of HGV transmission, other than transfusion or contamination during HD procedure, were suspected.
