A case of type 3 hyperlipoproteinemia associated with generalized tuberoeruptive xanthomas.
- Author:
Eun Young KIM
1
;
Ki Woo SEO
;
Jung Eun KIM
;
Eun Jeong CHO
;
Wang Soo LEE
;
Chee Jeong KIM
;
Kap Sok LI
Author Information
1. Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea. cjkim@cau.ac.kr
- Publication Type:Case Report
- Keywords:
Type 3 hyperlipoproteinemia;
Apolipoprotein E
- MeSH:
Alleles;
Apolipoproteins;
Arginine;
Buttocks;
Cholesterol;
Citrus sinensis;
Cysteine;
Elbow;
Electrophoresis;
Female;
Fenofibrate;
Heptanoic Acids;
Humans;
Hyperlipoproteinemia Type III;
Hyperlipoproteinemias;
Lipoproteins;
Middle Aged;
Pyrroles;
Xanthomatosis;
Atorvastatin Calcium
- From:Korean Journal of Medicine
2009;77(5):620-624
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 55-year-old female presented with extensive yellowish eruptive plaques over both elbows and the buttocks that she had first noticed 2 years earlier. Yellowish orange discoloration of her palmar creases was noted. Her serum cholesterol and triglyceride were markedly elevated. Lipoprotein electrophoresis showed a broad beta band. On apolipoprotein E genotyping, the arginine at position 158 had been replaced by cysteine in both alleles (E2/E2). Under a diagnosis of type III hyperlipoproteinemia, combined atorvastatin and fenofibrate therapy for 2 months normalized the serum cholesterol and triglyceride levels.
