A case of peripheral T-cell lymphoma with central nervous system and bilateral pulmonary involvement.
- Author:
Tai Yeon KOO
1
;
Byeong Bae PARK
;
Hye Young KIM
;
Won Jun KIM
;
Jung Hye CHOI
;
In Soon KIM
;
Young Yeol LEE
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. drbbpark@gmail.com
- Publication Type:Case Report
- Keywords:
Peripheral T-cell lymphoma;
Central nervous system and lung;
IMEP;
Stem cell transplantation
- MeSH:
Biopsy;
Central Nervous System;
Etoposide;
Humans;
Lung;
Lymphoma, B-Cell;
Lymphoma, Non-Hodgkin;
Lymphoma, T-Cell, Peripheral;
Methotrexate;
Middle Aged;
Paresthesia;
Stem Cell Transplantation;
T-Lymphocytes
- From:Korean Journal of Medicine
2009;77(5):643-648
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Mature T-cell non-Hodgkin's lymphoma (NHL) has more frequent extranodal involvement and is less sensitive to chemotherapy than B-cell lymphoma. Peripheral T-cell lymphoma unspecified (PTCL-U) is rarely combined with pulmonary or CNS involvement. We report a case of PTCL-U with lung and CNS involvement that was treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). A 62-year-old man was admitted with right-side weakness and paresthesias, and was diagnosed with PTCL-U after alung biopsy. Successful complete remission was achieved after threecycles of IMEP (ifosfamide, methotrexate, etoposide, and prednisone) chemotherapywith concurrent intrathecal chemotherapy and subsequent high-dose chemotherapy with ASCT to treat potential advanced stage PTCL-U. The non-anthracycline-containing IMEP regimen can be effective for PTCL-U, especially in cases with CNS involvement.
