Genetic Polymorphisms in the HTR2C and Peroxisome Proliferator-Activated Receptors Are Not Associated with Metabolic Syndrome in Patients with Schizophrenia Taking Clozapine.
- Author:
Shi Hyun KANG
1
;
Jong Il LEE
;
An Kee CHANG
;
Yeon Ho JOO
;
Chang Yoon KIM
;
Seong Yoon KIM
Author Information
1. Department of Psychiatry, Seoul National Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Metabolic syndrome;
Clozapine;
HTR2C;
PPAR;
Polymorphism;
Schizophrenia
- MeSH:
Adult;
Blood Pressure;
Cholesterol;
Clozapine;
Cross-Sectional Studies;
Female;
Gene Frequency;
Genetic Variation;
Genotype;
Glucose;
Humans;
Logistic Models;
Male;
Peroxisome Proliferator-Activated Receptors;
Peroxisomes;
Polymorphism, Genetic;
PPAR alpha;
PPAR gamma;
Prevalence;
Receptors, Cytoplasmic and Nuclear;
Schizophrenia;
Triglycerides;
Waist Circumference;
Weight Gain
- From:Psychiatry Investigation
2011;8(3):262-268
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Genetic variation in the serotonin-2C receptor encoded by the HTR2C gene is one of the genetic determinants of antipsychotic-induced weight gain. Peroxisome proliferator-activated receptors are nuclear receptors regulating the expression of genes involved in lipid and glucose metabolism. In this cross-sectional study, we investigated whether HTR2C-759C/T, HTR2C-697G/C, PPARalpha V227A, and PPARgamma 161C/T genotypes were associated with metabolic syndrome (MetS) in patients with schizophrenia taking clozapine. METHODS: One hundred forty-six Korean patients using clozapine for more than one year were genotyped for the HTR2C-759C/T, HTR2C-697G/C, PPARalpha V227A, and PPARgamma 161C/T polymorphisms, and their weight, waist circumference, blood pressure, triglycerides, high-density lipoprotein-cholesterol, total cholesterol, and glucose were measured. We used the criteria for MetS proposed by the National Cholesterol Education Program-adapted Adult Treatment Panel III. RESULTS: The prevalence of MetS was 47.3% and was similar among men (49%) and women (42.9%). We found no significant differences between patients with and without MetS in terms of genotypes or allele frequencies. Logistic regression analyses also revealed no association between MetS and each genotype. CONCLUSION: We did not find significant associations between four polymorphisms (HTR2C-759C/T, HTR2C-697G/C, PPARalpha V227A, and PPARgamma 161C/T) and MetS in patients with schizophrenia taking clozapine.
