The Change of Corneal Endothelial Permeability and Corneal Thickness after Topical Steroid Treatment.
- Author:
Jun Sung PARK
1
;
Sang Hwan BAE
;
Ki San KIM
Author Information
1. Department of Ophthalmology, Masan Samsung Hospital, Sungkyunkwan University School of Medicine, Masan, Korea.
- Publication Type:Original Article
- Keywords:
Corneal endothelial permeability;
Corneal thickness;
Dexamethasone;
Prednisolone acetate
- MeSH:
Dexamethasone;
Ophthalmic Solutions;
Permeability*;
Prednisolone;
Rabbits
- From:Journal of the Korean Ophthalmological Society
2001;42(2):342-348
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Changes of corneal endothelial permeability and corneal thickness after instillation of topical steroid was evaluated. In five rabbits, 0.1%dexamethasone eye solution was dropped into right eyes, and in another five rabbits, 1%prednisolone acetate eye solution was dropped into right eyes, and each left eyes were used as a control with dropping of Tears Naturale(r)II (Alcon-couvreur, Belgium). After dropping eyedrops for seven days, corneal endothelial permeability and corneal thickness were measured. Mean corneal thickness changed from 371.4 micrometer to 334.2 micrometer after dropping eyedrops in 0.1%dexamethasone group, and from 375.8 micrometer to 347.8 micrometer in control group where no statistical difference was noted between the two groups. Corneal endothelial permeability was 3.58x10(-4)cm/min in 0.1%dexamethasone group, and 3.54x10(-4) cm/min in control group(p>0.05). Mean corneal thickness changed from 347.4 micrometer to 323.8 micrometer after dropping eyedrops in 1% prednisolone acetate group, and from 342.4 micrometer to 335.6 micrometer in control group. There was also no statistical difference between the two groups. Corneal endothelial permeability was 4.08x10(-4)cm/min in 1%prednisolone acetate group, and 4.26x10(-4) cm/min in control group(p>0.05). In conclusion, topical application of 0.1%dexamethasone or 1%prednisolone acetate for a short period may have no effect on corneal endothelial permeability and thickness.
