Activation of Caspase-3 During Photoreceptor Degeneration in rd Mouse Retina.
- Author:
Dong Hwan KIM
1
;
Jeong A KIM
;
Choun Ki JOO
Author Information
1. Department of Ophthalmology, College of Medicine, The Catholic University of Korea.
- Publication Type:Original Article
- Keywords:
Apoptosis;
Caspase-3;
cGMP-phosphodiesterase(PDE);
rdmouse(FVB/N);
Retinal degeneration
- MeSH:
Animals;
Apoptosis;
Blindness;
Caspase 3*;
Cell Death;
Genome;
Mice*;
Models, Animal;
Necrosis;
Retina*;
Retinal Degeneration
- From:Journal of the Korean Ophthalmological Society
2001;42(2):365-372
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Retinal degeneration caused by a hereditary defect in the genome is reported in a few animals and it leads to blindness. rd mouse is one of the well studied animal models for retinal degeneration. The retinal degeneration of rd mouse is caused by a mutation on cGMP-phosphodiesterase(PDE). Caspase activation has been implicated for apoptosis. In this study, we examined the activation of caspase-3 during photoreceptor degeneration in rdmouse. Photoreceptor degeneration of rd mouse occured at PD 9 and disappeared at PD 21.In addition, we observed the active form of caspase-3 in the retinal degeneration of rd mouse. In conclusion, the cell death pattern of photoreceptor degeneration in rd mouse seemed to be an apoptosis rather than necrosis.
