Outer Blood-retinal Barrier Alteration Induced by Intraocular Ad vanced Glycation Endproduct.
- Author:
Seok Joon PARK
1
;
Chung Hum CHUNG
Author Information
1. Department of Ophthalmology, Seoul Municipal Boramae Hospital.
- Publication Type:Original Article
- Keywords:
Advanced glycation endproduct;
Outer blood-retinal barrier;
Permeability
- MeSH:
Blood-Retinal Barrier*;
Diabetic Retinopathy;
Permeability;
Retina;
Retinal Pigment Epithelium;
Retinaldehyde
- From:Journal of the Korean Ophthalmological Society
2001;42(2):373-377
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Advanced glycation end-product(AGE)is known as a factor causing diabetic retinopathy, but little is known about its effect on the function of outer blood-retinal barrier. To test whether AGE can increase the permeability of outer blood-retinal barrier, we injected glycated albumin into white rabbit eyes and observed the change of the fundus and of the outer blood-retinal barrier permeability. The rabbit retina in medullary ray was thickened in AGE-injected eyes. Intravenously injected microperoxidase, tracer molecule, was found in outer sensory retinal layer and outside of the retinal pigment epithelium in AGE-injected eyes. These results suggest that intraocularly injected AGE can increase the outer blood-retinal barrier permeability.
