Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice.
10.3344/kjp.2009.22.3.206
- Author:
Sun Seek MIN
1
;
Seung Ho HAN
;
Jaeyong YEE
;
Chan KIM
;
Geun Hee SEOL
;
Jae Hyeung IM
;
Hyung Tae KIM
;
Kyu Chang LEE
;
Hye Young KIM
;
Myeong Jong LEE
Author Information
1. Department of Physiology and Biophysics, College of Medicine, Eulji University, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
antinociception;
essential oil of ocimum basilicum;
formalin test;
plantar test
- MeSH:
Animals;
Formaldehyde;
Hand;
Medicine, Traditional;
Mice;
Ocimum;
Ocimum basilicum;
Pain Measurement
- From:The Korean Journal of Pain
2009;22(3):206-209
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB. METHODS: This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 mg/kg, 100 mg/kg, 150 mg/kg) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 mg/kg, 100 mg/kg) was administered and the withdrawal latency was measured using the Hargreaves method. RESULTS: In the formalin test, EOOB (50 mg/kg, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined. CONCLUSIONS: These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
