Effect of intraperitoneal injection of single chemotherapeutic agent on rat bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.
- Author:
Sang Gyu KIM
1
;
Kwan Gyu PARK
;
Chun Il KIM
;
Sung Choon LEE
Author Information
1. Department of Urology, Keimyung University, School of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Bladder tumor;
BBN
- MeSH:
Animals;
Carcinogenesis*;
Cisplatin;
Doxorubicin;
Female;
Humans;
Injections, Intraperitoneal*;
Mucous Membrane;
Rats*;
Rats, Sprague-Dawley;
Urinary Bladder Neoplasms;
Urinary Bladder*
- From:Korean Journal of Urology
1991;32(2):177-183
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Chemotherapeutic agents were evaluated for their effect on the development of urinary bladder tumors, induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in female Sprague-Dawley rats. For 16 weeks, 0.05% BBN was administered orally, and then chemotherapeutic agents (adriamycin and cisplatin) were injected intraperitoneally for 12 weeks. In our preliminary experimental series, an experimental bladder tumor model induced by BBN was useful in evaluating the effectiveness of chemotherapeutic agents. Cisplatin appears to be effective in inhibiting precancerous histologic changes and carcinoma in rat urinary bladder mucosa by BBN. However, the effectiveness of adriamycin was inconclusive.
