Glutathione S-Transferase Polymorphisms and Genetic Susceptibility to Cervical Cancer.
- Author:
Jin Woo KIM
1
;
Chun Geun LEE
;
Yeo Won SOHN
;
Hong Ki MIN
;
Su Mi HAN
;
Eun Young CHO
;
Kyung Sook KIM
;
Jin Woong SHIN
;
Sa Jin KIM
;
Tae Chul PARK
;
Joon Mo LEE
;
Sung Eun NAMKOONG
Author Information
1. Department of Obstetrics and Gynecology, Catholic University Medical College, Korea.
- Publication Type:Original Article
- Keywords:
Cervical cancer;
Genetic susceptibility;
Glutathione S-Transferase
- MeSH:
Adult;
Alleles;
DNA;
Genetic Predisposition to Disease*;
Genotype;
Glutathione Transferase*;
Glutathione*;
Humans;
Incidence;
Isoenzymes;
Korea;
Metabolism;
Polymerase Chain Reaction;
Uterine Cervical Neoplasms*
- From:Journal of the Korean Cancer Association
1997;29(4):673-680
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The identification of genetic traits that predispose individuals to environmentally induced cancers is one of the challanges in the assessment of individual cancer risk. The genetically determined differences in metabolism, related to glutathione S-transferases (GSTs) have been reported to be associated with various cancer susceptibility. The present study was set up to establish the frequencies of the polymorphic genotypes of two GST (GST- mu and GST-theta) isozymes in Korea, to evaluate a possible increased incidence of the genotypes associated with higher cervical cancer risks among Korean cervical cancer patients. MATERIALS AND METHODS: In this study, extracted DNAs from cervical cancer patients (228 for GST-mu and 241 for GST-theta genotypes) and normal controls (360 for GST-mu and 353 for GST-theta genotypes) were analysed with the polymerase chain reaction (PCR). RESULTS: The overall genotype distribution of the GST-theta polymorphisms was not statistically different between the patients and control groups. But, in the GST-mu null genotypes, there were remarkable differences between patients and control groups when the cervical cancer patients were devided into subgroups with respect to the age. The frequency of GST-mu null polymorphisms in the cervical cancer patients under the 40 years old was significantly higher compared to the patients above the 40 years old (0.01
