The role of E-cadherin expression in non-small cell lung cancer.
10.3346/jkms.2000.15.5.501
- Author:
Sung Chul LIM
1
;
Il Gweon JANG
;
Young Chul KIM
;
Kyung Ok PARK
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea. lscmd@chonnam.chonnam.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Cadherins;
Lung Neoplasms;
Lymph Nodes
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Antibodies, Monoclonal;
Cadherins/immunology;
Cadherins/biosynthesis*;
Cadherins/analysis*;
Carcinoma, Non-Small-Cell Lung/pathology*;
Carcinoma, Non-Small-Cell Lung/metabolism;
Carcinoma, Non-Small-Cell Lung/chemistry;
Female;
Human;
Immunohistochemistry;
Lung Neoplasms/pathology*;
Lung Neoplasms/metabolism;
Lung Neoplasms/chemistry;
Lymph Nodes/pathology;
Male;
Middle Age;
Predictive Value of Tests;
Prognosis
- From:Journal of Korean Medical Science
2000;15(5):501-506
- CountryRepublic of Korea
- Language:English
-
Abstract:
The purpose of this study is to evaluate the clinical significance of E-cadherin expression in lung cancer. E-cadherin expression was detected by immunohistochemistry using a monoclonal antibody (HECD-1). Strongly positive (++) E-cadherin tumors were classified as a type of preserved E-cadherin expression (Pr type), while the others (+, - tumors) were classified as a type of reduced E-cadherin expression (Rd type). The frequency of Pr type in squamous cell carcinomas (59.0%) was higher than Rd type. However, in adenocarcinomas, the frequency of Rd type was higher than Pr type. E-cadherin expression pattern was significantly correlated with differentiated state (Pearson correlation coefficient 0.394, p>0.001). E-cadherin expression of well-differentiated tumors was more frequently preserved than that of poorly differentiated tumors (60.0% vs. 25.9%). With regard to the correlation between E-cadherin expression and stages of lymph node metastasis in non-small cell lung cancers, the percentage of tumors with Pr type E-cadherin expression declined from 66.3% (> or = N1) to 38.6% (> or = N2), indicating that loss of E-cadherin expression is responsible for acquisition of invasive potential of lung cancer as well as the possible role of E-cadherin in the histological differentiation of lung cancer.
