Sebaceous carcinoma of the eyelids: frequent expression of c-erbB-2 oncoprotein.
10.3346/jkms.2000.15.5.545
- Author:
Kyung Ja CHO
1
;
Shin Kwang KHANG
;
Jae Soo KOH
;
Jin Haeng CHUNG
;
Seung Sook LEE
Author Information
1. Department of Pathology, University of Ulsan College of Medicine, Seoul, Korea. kjc@www.amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Carcinoma;
Sebaceous Glands;
Eyelids;
Immunohistochemistry;
erbB-2;
Receptors, Estrogen;
Receptors, Progesterone
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Carcinoma/pathology*;
Carcinoma/metabolism;
Carcinoma/chemistry;
Eyelid Neoplasms/pathology*;
Eyelid Neoplasms/metabolism;
Eyelid Neoplasms/chemistry;
Female;
Human;
Immunohistochemistry;
Male;
Middle Age;
Necrosis;
Receptor, erbB-2/biosynthesis*;
Receptor, erbB-2/analysis;
Receptors, Estrogen/analysis;
Receptors, Progesterone/analysis;
Sebaceous Gland Neoplasms/pathology*;
Sebaceous Gland Neoplasms/metabolism;
Sebaceous Gland Neoplasms/chemistry
- From:Journal of Korean Medical Science
2000;15(5):545-550
- CountryRepublic of Korea
- Language:English
-
Abstract:
Ocular sebaceous carcinoma (OSC) is an uncommon malignancy with a potential to recur and metastasize. Some characteristics of sebaceous carcinoma, such as female preponderance, shown in the present series during 11-year period at Korea Cancer Center Hospital, led us to study their hormone receptors and c-erbB-2 expression. c-erbB-2 overexpression was very common (83%) in OSC, and was not associated with pathologic findings or clinical outcome. Interestingly, estrogen and progesterone receptor was detected in 4 and 2 cases, respectively, suggesting a role of hormonal influence on this neoplasm. Immunohistochemical and clinicopathologic features of 18 cases of OSC in Korea are presented.
