Churg-Strauss syndrome with perforating ulcers of the colon.
10.3346/jkms.2000.15.5.585
- Author:
Young Bae KIM
1
;
Seung Won CHOI
;
In Seo PARK
;
Jee Young HAN
;
Yoon Seok HUR
;
Young Chae CHU
Author Information
1. Department of Pathology, Inha University College of Medicine, Inchon, Korea.
- Publication Type:Case Report
- Keywords:
Churg-Strauss Syndrome;
Intestinal Perforation;
Hepatitis B
- MeSH:
Aged;
Case Report;
Churg-Strauss Syndrome/virology;
Churg-Strauss Syndrome/pathology;
Churg-Strauss Syndrome/complications*;
Colon/virology;
Colon/pathology*;
Colonic Diseases/virology;
Colonic Diseases/pathology;
Colonic Diseases/etiology*;
Female;
Hepatitis B/pathology;
Hepatitis B Antigens/analysis;
Human;
Immunohistochemistry;
Intestinal Perforation/virology;
Intestinal Perforation/pathology;
Intestinal Perforation/etiology*
- From:Journal of Korean Medical Science
2000;15(5):585-588
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of a 72-year-old woman with Churg-Strauss syndrome, who presented with intestinal perforation. She has had bronchial asthma with peripheral blood eosinophilia for 30 years. Gross findings of a resected colon showed multiple ulcers with perforation. Histologic findings demonstrated transmural inflammation infiltrated with large numbers of eosionophils, neutrophils and lymphoplasma cells, and characteristic extravascular granuloma in the subserosa. There were multifocally-distributed transmural vasculitis showing all stages of activity in medium and small-sized arteries and veins located in the submucosa, and proper muscle and subserosal layers of the colon, some of which revealed granulomatous inflammation. Histologic finding of liver showed chronic viral hepatitis B with mild inflammatory activity and macronodular cirrhosis. Immunohistochemical findings, acid fuschin orange G staining and electromicroscope found no evidence of hepatitis B virus infection contributing to the pathogenesis of this lesion.
