Significance of Inflammatory Markers in Diabetic Patients with Stable Coronary Artery Disease.
10.3904/kjim.2009.24.3.212
- Author:
Hyo Jin LEE
1
;
Sung Ho HER
;
Yun Sun IM
;
Kang Yeon WON
;
Sun Hong YOO
;
Dong Bin KIM
;
Dong Il SHIN
;
Pum Joon KIM
;
Ki Bae SEUNG
;
Jae Hyung KIM
;
Keon Yeop KIM
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. hhhsungho@naver.com
- Publication Type:Original Article
- Keywords:
C-reactive protein;
Diabetes mellitus;
Coronary artery disease, stable
- MeSH:
Adult;
Aged;
Biological Markers;
C-Reactive Protein/*analysis;
Coronary Artery Disease/*blood;
Diabetes Complications/*blood;
Female;
Hemoglobin A, Glycosylated/analysis;
Humans;
Logistic Models;
Male;
Middle Aged
- From:The Korean Journal of Internal Medicine
2009;24(3):212-219
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Patients with diabetes are prone to coronary artery disease (CAD); however, the majority of diabetic patients show normal coronary arteries. We examined differences in the clinical aspects of diabetic patients with insignificant and with significant stenosis of the coronary artery. METHODS: A total of 418 consecutive diabetic patients with stable angina who had undergone coronary angiography from January 2004 to March 2007 were included in this study. Patients were subdivided into control and CAD groups and then clinical characteristics and CAD-associated factors were evaluated. RESULTS: A total of 92 (22%) patients were assigned to the control group and 326 (78%) patients were assigned to the CAD group. Using univariate regression analysis, we found that patients with CAD were significantly older (control vs. CAD; 59+/-21 vs. 64.7+/-33.7, years, p<0.001), had a longer duration of diabetes (8.2+/-21.8 vs. 10.2+/-29.8, years, p=0.027), higher titers of high sensitivity C-reactive protein (hsCRP; 0.3+/-6.79 vs. 0.9+/-12.6, mg/dL, p=0.015), and increased hemoglobin A1c (HbA1c) levels (7.1+/-3.8 vs. 7.5+/-4.8, %, p=0.007) compared to control patients. Multivariate regression analysis showed that only differences in age, hsCRP, and HbA1c were statistically significant. When patients were subdivided into groups based on hsCRP levels (208 patients in the low group [49.8%], 210 patients in the high group [50.2%]), we found that patients with higher hsCRP levels showed more frequent multivessel disease. CONCLUSIONS: In diabetic patients, age, hsCRP, and HbA1c were associated with stable CAD. Among these factors, hsCRP levels were significantly correlated with multivessel involvement in diabetic CAD. Therefore, high hsCRP levels may be a strong predictor for atherosclerotic progression of the coronary arteries in diabetic patients, suggesting that regular screening tests should be performed.
