Adenosine 5'-triphosphate induced NF-kappa B and intracellular calcium mobilization in cervical cancer cells.
- Author:
Dae Seog LIM
1
;
Su Mi BAE
;
Sun Young KWAK
;
Guo Hua DING
;
Jeong KIM
;
Yong Wook KIM
;
Duck Yeong RO
;
Joon Mo LEE
;
Seung Eun NAMKOONG
;
Young Lae CHO
;
Sei Jun HAN
;
Gye Hyun NAM
;
Byung Don HAN
;
Chong Kook KIM
;
Woong Shick AHN
Author Information
1. Catholic Research Institutes of Medical Science, College of Medicine, The Catholic University of Korea.
- Publication Type:Original Article
- Keywords:
ATP;
Cervical cancer cells;
Calcium mobilization;
Proliferation;
NF-kappa B
- MeSH:
Adenosine Triphosphate;
Adenosine*;
Calcium*;
Cell Line;
Cell Proliferation;
Humans;
NF-kappa B*;
Transcription Factors;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
2005;48(12):2903-2909
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To know the effect of adenosine 5'-triphosphate (ATP) on intracellular calcium level and cell proliferation in cervical cancer cells. METHODS: Study design: Four different human cervical cancer cell lines (Caski, C33A, HeLaS3 and SiHa) were used in this study. The change of intracellular calcium level, cell proliferation and the activity of proliferation- and calcium-related transcription factors by extracellular ATP were examined in these cell lines. RESULTS: Extracellular ATP induced calcium mobilization, cell proliferation and the activation of NF-kappa B in all cell lines used. CONCLUSION: These results suggest that calcium mobilization and NF-kappa B dependent signaling pathway play an important role in the cell proliferation by ATP in cervical cancer.
