Application on the analytical methods in the evaluation of bioavalability of some manufactured product of paracetamol
- Author:
Ha Thi Pham
- Publication Type:Journal Article
- Keywords:
paracetamol
- MeSH:
Acetaminophen;
Biological Availability;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
1999;281(9):20-23
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The concentration of paracetamol in rabbit blood is determined by HPLC with UV detection at the wavelength of 257 nm and mobile phase of CH3OH-H2¬O-CH3COOH (20:79:1). We have determined the extent and rate of drug absorption into blood (through Cmax, Tmax and AUC calculated from the blood concentrations) and the extent and rate of dissolution (by the dissolution test mainly based on the paddle method described in USP 23) with 3 different finished products of paracetamol (by two Vietnamese manufacturers and by Smithkline Beecham) of the same dosage form (500 mg tablet). The test was carried out on 5 rabbits for each product and the results showed that there was no significant difference between the domestic and foreign drugs in both dissolution and absorption
