Placental expression of D6 decoy receptor in preeclampsia.
10.5468/ogs.2015.58.5.333
- Author:
Geum Joon CHO
1
;
Eun Sung LEE
;
Hye Mi JIN
;
Ji Hye LEE
;
Yeun Sun KIM
;
Min Jeong OH
;
Hyun Joo SEOL
;
Soon Cheol HONG
;
Hai Joong KIM
Author Information
1. Department of Obstetrics and Gynecology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea. mjohmd@korea.ac.kr
- Publication Type:Original Article
- Keywords:
D6 decoy receptor;
Placenta;
Preeclampsia
- MeSH:
Blotting, Western;
Chemokines;
Female;
Humans;
Inflammation;
Placenta;
Pre-Eclampsia*;
Pregnancy;
Pregnancy Trimester, Third;
Pregnant Women;
Reverse Transcriptase Polymerase Chain Reaction;
RNA, Messenger
- From:Obstetrics & Gynecology Science
2015;58(5):333-339
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The purpose of this study was to investigate the expression of the D6 decoy receptor that can bind chemokines and target them for degradation, resulting in inhibition of inflammation in placentas from preeclamptic and normal pregnancies. METHODS: The current study was carried out in 35 pregnant women (23 patients with preeclampsia and 12 healthy, normotensive pregnant women) during the third trimester of pregnancy. The expressions of D6 decoy receptor in the placenta were determined with real time reverse transcriptase polymerase chain reaction and western blotting. RESULTS: The mRNA and protein of D6 decoy receptor were detected in all of placentas from preeclamptic and normal pregnancies. Placental D6 decoy receptor mRNA expression was significantly lower in patients with preeclampsia than in patients with normal pregnancies. Western blot analyses revealed decreased protein expression in cases of preeclampsia. CONCLUSION: The expression of the D6 decoy receptor in preeclamptic placentas was significantly lower than in normal placentas. Further studies are needed to clarify the underlying mechanisms that link decreased expression of placental D6 decoy receptor and preeclampsia.
