A Case of Muir-Torre Syndrome with Multiple Cancers of Bilateral Eyelids and Breast.
10.3341/kjo.2013.27.3.204
- Author:
Taro KAMISASANUKI
1
;
Eisuke UCHINO
;
Jun Ichi FUKUSHIMA
;
Hiroshi YOSHIKAWA
;
Tatsuro ISHIBASHI
;
Taiji SAKAMOTO
Author Information
1. Department of Ophthalmology Faculty of Medicine, Kagoshima University Graduate School of Medicine and Dental Sciences, Kagoshima, Japan. tsakamot@m3.kufm.kagoshima-u.ac.jp
- Publication Type:Case Reports ; Research Support, Non-U.S. Gov't
- Keywords:
Breast neoplasms;
Eyelids;
Immunohistochemistry;
Pancreatic neoplasms
- MeSH:
Aged;
Breast Neoplasms/*pathology;
Eyelid Neoplasms/*pathology;
Family Health;
Female;
Humans;
Muir-Torre Syndrome/*pathology;
Neoplasms, Multiple Primary/*pathology
- From:Korean Journal of Ophthalmology
2013;27(3):204-207
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of Muir-Torre syndrome (MTS) with a very rare combination of cancers, involving bilateral eyelid cancers and breast cancer. A 71-year-old female with a history of breast cancer from 18 years prior presented with bilateral eyelid tumors. One of her siblings had lung cancer, and another had pancreatic cancer. She underwent excisional biopsy of the eyelid tumors and histopathology revealed sebaceous carcinoma of the right eyelid and basal cell carcinoma of the left. She was diagnosed with MTS: a skin cancer associated with visceral malignancy. Immunohistochemical tests for mutS homolog 2 showed a lack of expression in both eyelid carcinomas.
