Whole-Brain Diffusion-Tensor Changes in Parkinsonian Patients with Impulse Control Disorders.
- Author:
Hye Bin YOO
1
;
Jee Young LEE
;
Jae Sung LEE
;
Hyejin KANG
;
Yu Kyeong KIM
;
In Chan SONG
;
Dong Soo LEE
;
Beom Seok JEON
Author Information
- Publication Type:Original Article
- Keywords: impulse control disorders; Parkinson's disease; diffusion-tensor imaging
- MeSH: Anisotropy; Brain; Corpus Callosum; Extremities; Humans; Disruptive, Impulse Control, and Conduct Disorders*; Internal Capsule; Parkinson Disease
- From:Journal of Clinical Neurology 2015;11(1):42-47
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND AND PURPOSE: The aim of this study was to determine the changes in diffusion-tensor images associated with medication-related impulse control disorder (ICD) in Parkinson's disease (PD) patients undergoing chronic dopamine-replacement therapy. METHODS: Nineteen PD patients, comprising 10 with ICD (PD-ICD) and 9 without ICD (PD-nonICD), and 18 age-matched healthy controls (HCs) with no cognitive or other psychiatric disorders were analyzed. All subjects underwent 3-T magnetic resonance diffusion-tensor imaging. For all PD patients, clinical data on PD duration, antiparkinsonian medication dosages, Unified Parkinson's Disease Rating Scale and Mini-Mental State Examination were collected. Whole-brain voxel-based measures of fractional anisotropy (FA) and mean diffusivity (MD) were analyzed. RESULTS: In comparison with HCs, the PD-nonICD subjects had low FA at the bilateral orbitofrontal areas. While the PD-ICD subjects exhibited no such difference, their FA was significantly elevated at the anterior corpus callosum. Analysis of FA between the two PD groups revealed that FA in the anterior corpus callosum, right internal capsule posterior limbs, right posterior cingulum, and right thalamic radiations were significantly higher (corrected p<0.05) in the PD-ICD than in the PD-nonICD patients. MD did not differ between the PD-ICD and PD-nonICD groups in any brain regions. CONCLUSIONS: The PD-ICD patients appear to have relatively preserved white-matter integrity in the regions involved in reward-related behaviors compared to PD-nonICD patients. Further investigation is required to determine whether the difference in FA between PD-ICD and PD-nonICD patients reflects microstructural differences in the pathological progression of PD or is secondary to ICD.
