Correlation between Fluorescein Angiographic Findings and Visual Acuity in Behcet Retinal Vasculitis.
10.3349/ymj.2015.56.4.1087
- Author:
Min KIM
1
;
Hee Jung KWON
;
Eun Young CHOI
;
Sung Soo KIM
;
Hyoung Jun KOH
;
Sung Chul LEE
Author Information
1. Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Behcet retinal vasculitis;
ocular Behcet disease;
fluorescein angiography;
visual acuity
- MeSH:
Adult;
Aged;
Behcet Syndrome/*diagnosis;
Female;
*Fluorescein Angiography;
Fluoresceins;
Follow-Up Studies;
Humans;
Male;
Middle Aged;
Regression Analysis;
Retinal Vasculitis/*diagnosis/physiopathology;
Retrospective Studies;
Visual Acuity/*physiology
- From:Yonsei Medical Journal
2015;56(4):1087-1096
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To identify significant fluorescein angiographic (FA) characteristics associated with visual acuity (VA) in Behcet retinal vasculitis. MATERIALS AND METHODS: Retrospective review of 86 eyes of 48 patients (age: 35.6+/-10.2 years) with Behcet retinal vasculitis were performed. VA and FA findings as well as correlation between them were assessed. RESULTS: The mean initial VA of eyes with posterior pole-involved vasculitis (63 eyes; 73.3%) was significantly worse than that of those with peripheral vasculitis (23 eye; 26.7%) (logarithm of the minimum angle of resolution VA: 0.554+/-0.572 vs. 0.078+/-0.148; p<0.0001). Subgroup analysis revealed a more severe and diffuse pattern of vascular leakage in posterior pole-involved vasculitis compared to peripheral vasculitis (p<0.0001). Retinal vascular leakage (beta=0.345; p<0.0001), optic disc hyperfluorescence (beta=0.147; p=0.032), and macular leakage (beta=0.107; p=0.047) were significantly associated with worse initial VA. During the follow up (mean: 33.3+/-17.9 months), the change of leakage showed no significant correlation with change of VA in posterior pole-involved vasculitis (tau=0.199, p=0.092). CONCLUSION: Posterior pole involvement, the degree of retinal vascular leakage, optic disc hyperfluorescence, and macular leakage are significantly associated with VA in Behcet retinal vasculitis.
