Antiproliferative Effect and Safety of 5-Fluorouracil and Heparin in the Treatment of Proliferative Vitreoretinopathy.
- Author:
Ki Hwan CHOI
1
;
Sang Kook KIM
;
Se Woong KANG
Author Information
1. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. swkang@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
5-Fluorouracil;
Heparin;
Proliferative vitreoretinopathy
- MeSH:
Cataract;
Corneal Edema;
Fluorouracil*;
Follow-Up Studies;
Heparin*;
Heparin, Low-Molecular-Weight;
Humans;
Hyphema;
Incidence;
Intraocular Pressure;
Recurrence;
Retinal Detachment;
Retinaldehyde;
Retrospective Studies;
Visual Acuity;
Vitrectomy;
Vitreoretinopathy, Proliferative*;
Vitreous Hemorrhage
- From:Journal of the Korean Ophthalmological Society
2004;45(7):1099-1105
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Proliferative vitreoretinopathy (PVR) is a major cause of recurrence and failure after retinal reattachment surgery. We assessed the effect and safety of adjuvant combination therapy using 5-Fluorouracil (5-FU) and low molecular weight heparin (LMWH) for prevention of PVR after vitrectomy. METHODS: Infusion fluid supplemented with 200 micro gram/mln of 5-FU and 5 IU/ml of LMWH was used during vitrectomy for rhegmatogenous retinal detachment in 21 patients with PVR. Anatomical results, the occurrence of postoperative PVR, and best corrected visual acuity were assessed retrospectively after a minimum of 6-month follow-up. The occurrence of complication was investigated in 27 eyes including an additional 6 eyes without PVR. RESULTS: The primary success rate was 85.7% (18/21) and the incidence of postoperative PVR was 14.3% (3/21). There was hyphema or vitreous hemorrhage in 3 eyes (14.3%), and significant corneal edema in 1 eye (4.8%) immediately after operation. Those complications were resolved without surgical management. There was intraocular pressure elevation (47.6%), and progression of cataract (23.8%) after operation. Those were controlled with antiglaucoma medication or operation. CONCLUSIONS: The use of 5-FU and LMWH is relatively safe and is suggested to have an antiproliferative effect.
