Clinicopathologic Features of Granulomatous Mastitis.
- Author:
Yee Jeong KIM
1
;
Yoon Jung CHOI
;
Ji Young KIM
;
Hee Jung KIM
;
Yang Soon PARK
;
Soon Won HONG
;
Chanil PARK
;
Doyil KIM
;
Hyde LEE
;
Woo Hee JUNG
Author Information
1. Department of Pathology, Yong Dong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. jungwh96@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Granuloma;
Mastitis;
Tuberculosis;
Corynebacterium;
Polymerase chain reaction
- MeSH:
Abscess;
Bacteria;
Coloring Agents;
Corynebacterium;
Diagnosis;
Diagnosis, Differential;
Fat Necrosis;
Female;
Granuloma;
Granulomatous Mastitis*;
Humans;
Inflammation;
Lactation;
Mastitis;
Mycobacterium tuberculosis;
Periodic Acid;
Polymerase Chain Reaction;
Pregnancy;
Recurrence;
Staphylococcus aureus;
Tuberculosis
- From:Korean Journal of Pathology
2005;39(3):181-186
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Granulomatous mastitis (GM) is a rare chronic inflammatory condition that clinically mimics a carcinoma. The diagnosis of idiopathic GM depends on the exclusion of other granulomatous inflammations. The purpose of this study is to correlate the clinicopathological features of GM with etiologies. METHODS: We reviewed the clinical records of 58 cases that were histologically diagnosed as GM. We performed special stains for microorganisms such as Ziehl-Neelsen, periodic acid Schiff and gram stains, and polymerase chain reaction (PCR) for Mycobacterium tuberculosis (TB PCR). RESULTS: The mean age of patients was 35.3 years. Most patients were parous except three. Seven patients (12.1%) were related with pregnancy or lactation. TB PCR was positive in nine patients (15.5%). Five patients (8.6%) had gram positive bacilli that were recognizable as coryneform bacteria. Culture study demonstrated Staphylococcus aureus in only one case. Infectious GM had a greater tendency to form abscesses. Fat necrosis was more likely to be present in idiopathic GM, but other histological features were similar to each other. Twenty-two cases (37.9%) showed recurrence. CONCLUSIONS: We suggest that TB PCR and gram stain are essential tests for the differential diagnosis of GM, because the histologic features considerably overlap irrespective of the various etiologies.
