Analysis of the Causes of and Risk Factors for Mortality in the Surgical Repair of Interrupted Aortic Arch.
- Author:
Jeong Ryul LEE
1
;
Jae Gun KWAK
;
Ji Eun BAN
;
Woong Han KIM
;
Sung Hoon JIN
;
Yong Jin KIM
;
Joon Ryang RHO
;
Eun Jung BAE
;
Chung Il NOH
;
Yong Soo YUN
Author Information
1. Department of Thoracic and Cardiovascular Surgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul National University Hospital, Clinical Research Institute, Xenotransplantation Research Center, Kroea.
- Publication Type:Original Article
- Keywords:
Aortic arch interruption;
Aorta, arch
- MeSH:
Alprostadil;
Anoxia;
Aorta, Thoracic*;
Body Weight;
Cardiopulmonary Bypass;
Cause of Death;
Constriction, Pathologic;
Diagnosis;
Heart;
Humans;
Mitral Valve Insufficiency;
Mortality*;
Operative Time;
Prostaglandins E;
Retrospective Studies;
Risk Factors*
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2006;39(2):99-105
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Interrupted aortic arch is a rare congenital heart anomaly which still shows high surgical mortality. In this study, we investigated the causes of and the risk factors for mortality to improve the surgical outcomes for this difficult disease entity. MATERIAL AND METHOD: From 1984 to 2004, 42 patients diagnosed as IAA were reviewed retrospectively. Age, body weight at operation, preoperative diagnosis, preoperative PGE 1 requirement, type of interrupted aortic arch, degree of left ventricular outflow stenosis, CPB time, and ACC time were the possible risk factors for mortality. RESULT: There were 14 hospital deaths. Preoperative use of PGE1, need for circulartory assist and aortic cross clamp time proved to be positive risk factors for mortality on univariate analysis. Preoperative left ventricular outflow stenosis was considered a risk factor for mortality but it did not show statistical significance (p-value=0.61). Causes of death included hypoxia due to pulmonary banding, left ventricular outtract stenosis, infection, mitral valve regurgitation, long cardiopulmonary bypass time and failure of coronary transfer failure in TGA patients. CONCLUSION: In this study, we demonstrated that surgical mortality is still high due to the risk factors including preoperative status and long operative time. However preoperative subaortic dimension was not related statistically to operative death statistically. Adequate preoperative management and short operation time are mandatory for better survival outcome.
