Comparison of Cognitive Effects of Lamotrigine and Oxcarbazepine in Epilepsy Patients.
- Author:
Jong Geun SEO
1
;
Da In LEE
;
Yang Ha HWANG
;
Ho Won LEE
;
Doo Kyo JUNG
;
Chung Kyu SUH
;
Soon Hak KWON
;
Sung Pa PARK
Author Information
- Publication Type:Original Article
- Keywords: Adverse effects; Cognition; Lamotrigine; Oxcarbazepine
- MeSH: Cognition; Epilepsy*; Humans; Incidence; Neuropsychological Tests; Retrospective Studies; Seizures; Trail Making Test
- From:Journal of Clinical Neurology 2007;3(1):31-37
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND AND PURPOSE: This study compared the cognitive effects of 1 year of treatment with lamotrigine (LTG) and oxcarbazepine (OXC) in epilepsy patients. METHODS: This retrospective study investigated 60 epilepsy patients undergoing neuropsychological tests who were either newly diagnosed or untreated in the preceding 6 months. The cognitive function in 30 patients receiving LTG monotherapy and 30 age-matched patients receiving OXC monotherapy was compared after 1 year. The neuropsychological scores at baseline and all of the epilepsy-relevant variables except seizure type did not differ between the groups. The mean daily dosages of LTG and OXC at 1 year were 93 mg and 825 mg, respectively. RESULTS: The posttreatment list-learning performance was better in the LTG group than in the OXC group (p<0.05). The incidence of cognitive complaints did not differ between the two groups. The list-learning performance and Trail Making Test scores were better in each group after treatment. CONCLUSIONS: LTG and OXC monotherapies have similar, slightly beneficial effects on cognitive function, and are probably not harmful.
