Rapidly Progressive Toxic Leukoencephalomyelopathy with Myelodysplastic Syndrome: a Clinicopathological Correlation.
- Author:
Keun Hwa JUNG
1
;
Kon CHU
;
Young A KIM
;
Beom S JEON
Author Information
- Publication Type:Case Report
- Keywords: Toxic leukoencephalomyelopathy; Organic solvent; Toluene; Myelodysplastic syndrome
- MeSH: Adult; Autopsy; Blood Vessels; Bone Marrow; Brain; Central Nervous System; Demyelinating Diseases; Estrogens, Conjugated (USP); Humans; Leg; Myelodysplastic Syndromes*; Necrosis; Nervous System Diseases; Nylons; Seizures; Solvents; Spinal Cord; Toluene
- From:Journal of Clinical Neurology 2007;3(1):45-49
- CountryRepublic of Korea
- Language:English
- Abstract: Neurological disorders induced by long-term exposure to organic solvents typically have a slowly progressive clinical course, which may be arrested or even reversed following discontinuation of exposure. We report an unusual case of rapidly progressive toxic leukoencephalomyelopathy in a 29-year-old man who had worked at a chemical factory that used toluene for the manufacture of nylon 66 for 5 years. He presented with progressive weakness of legs, recurrent seizures, and cognitive decline. Widespread white-matter changes in the brain and spinal cord, and myelodysplastic syndrome were noted. He died 6 months after the onset of his symptoms, and autopsy showed discrete multifocal demyelination and necrosis in the central nervous system, and dysplastic cells of erythroid, myeloid, and megakaryotic lineages in blood vessels. The co-occurrence of leukoencephalomyelopathy and myelodysplastic syndrome highlights the vulnerability of the white matter and bone marrow to injury from organic solvents. Intravascular congestion of dysplastic hematopoietic cells might have led to his unusually rapid progression of leukoencephalomyelopathy.
