Role of TGF-1 and TGF-beta Type II receptor in gastric cancer.
- Author:
Dong Il PARK
1
;
Hee Jung SON
;
Sang Yong SONG
;
Won Hyeok CHOE
;
Yun Jeong LIM
;
Sang Jong PARK
;
Jae J KIM
;
Young Ho KIM
;
Poong Lyul RHEE
;
Seung Woon PAIK
;
Jong Chul RHEE
;
Kyoo Wan CHOI
Author Information
1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
TGF-beta-1;
Receptor, TGF-beta type II;
Stomach neoplasms
- MeSH:
Carcinogenesis;
Classification;
Epithelial Cells;
Humans;
Lymph Nodes;
Receptors, Transforming Growth Factor beta;
RNA, Messenger;
Stomach Neoplasms*;
Transforming Growth Factor beta*;
Transforming Growth Factor beta1;
United Nations
- From:Korean Journal of Medicine
2001;61(4):409-416
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Transforming growth factor-beta (TGF-beta) is a potent inhibitor of epithelial cell growth. However, carcinoma cells, unlike normal cells, can escape from negative regulation by TGF-beta through lack of expression or mutation of TGF-beta receptor gene. In this study, we investigated the role of TGF-beta1 and TGF-beta type II receptors (TbetaR-II) in the progression of gastric cancer. METHODS: We analyzed TGF-beta1 and TbetaR-II mRNA expression semi-quantitatively, measured by comparative RT-PCR using GAPDH, in 23 patients who underwent gastric resection for gastric cancer. We analyzed the relationship between the clinicopathologic findings and the level of the TGF-beta1 and TbetaR-II mRNA expression in carcinoma tissues and in adjacent normal tissues of gastric cancer. RESULTS: (1) TGF-beta1 and TbetaR-II mRNA were expressed in all of the carcinoma tissues and adjacent normal tissues without statistical difference in the level of the expression. (2) The level of TGF-beta1 mRNA expression was higher in patients with early gastric cancer, negative lymph nodes or negative perineural invasion. There was no significant correlation between the level of TGF-beta1 mRNA expression and several parameters such as age, gender, tumor size, differentiation, Lauren's classification, and vascular invasion. (3) There was no significant correlation between the level of TbetaR-II mRNA expression and several prognostic variables described above. (4) There was significant correlation between the level of TGF-beta1 and TbetaR-II mRNA in carcinoma tissues. CONCLUSION: The above data indicates that TGF-beta1 may contribute in the early stages of gastric carcinogenesis. Further studies are required to clarify the role of TGF-beta 1 in gastric carcinogenesis.
