Cyclophosphamide: Induced lung toxicity in a patient with Wegener's granulomatosis.
- Author:
Kyoung Ai MA
1
;
Young Il CHOI
;
Cheol EOM
;
Jin Ho LEE
;
Young In CHOI
;
Myong Ho HAN
;
Kyung Ju PARK
;
Hyunee YIM
;
Gyu Tae SHIN
;
Heung Soo KIM
;
Do Hun KIM
Author Information
1. Department of Nephrology, School of Medicine, Ajou University, Suwon, Korea.
- Publication Type:Case Report
- Keywords:
Cyclophosphamide;
Drug toxicity;
Lung
- MeSH:
Cyclophosphamide*;
Drug-Related Side Effects and Adverse Reactions;
Dyspnea;
Female;
Glass;
Humans;
Idiopathic Pulmonary Fibrosis;
Korea;
Lung*;
Pneumonia;
Thorax;
Wegener Granulomatosis*
- From:Korean Journal of Medicine
2001;61(4):439-443
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Lung toxicity associated with cyclophosphamide use is a rare but serious side effect, that may result in a fatal course. However no such cases have been reported in Korea, so clinicians would not be alert to this adverse effect. We recently experienced a woman with Wegener's granulomatosis and idiopathic pulmonary fibrosis. This patient had been administered 12 grams of cyclophosphamide for 4 months. At that time of admission, She felt aggravating dyspnea on exertion for 2 weeks. Her chest x-ray and high resolution CT revealed aggravated reticular opacities and ground glass appearances. Dyspnea was improved and ground glass appearances on HRCT was disappeared after discontinuation of cyclophosphamide. We diagnosed this case as cyclophosphamide-induced pneumonitis and report it with a brief review of the literature.
