Clinical Guidelines for the Diagnosis and Treatment of Cushing's Disease in Korea.
- Author:
Kyu Yeon HUR
1
;
Jung Hee KIM
;
Byung Joon KIM
;
Min Seon KIM
;
Eun Jig LEE
;
Sung Woon KIM
Author Information
- Publication Type:Review
- Keywords: Adrenocorticotropic hormone; Corticotropin-releasing hormone; Pituitary ACTH hypersecretion; Cushing's disease; Inferior petrosal sinus sampling; Pasireotide; Pituitary adenomas; Transsphenoidal approach
- MeSH: Adrenal Glands; Adrenocorticotropic Hormone; Corticotropin-Releasing Hormone; Cushing Syndrome; Diagnosis*; Hirsutism; Humans; Hydrocortisone; Korea; Mass Screening; Mortality; Obesity, Abdominal; Petrosal Sinus Sampling; Pituitary ACTH Hypersecretion; Pituitary Neoplasms
- From:Endocrinology and Metabolism 2015;30(1):7-18
- CountryRepublic of Korea
- Language:English
- Abstract: Cushing's disease (CD) is a rare disorder characterized by the overproduction of adrenocorticotropic hormone due to a pituitary adenoma that ultimately stimulates excessive cortisol secretion from the adrenal glands. Prior to the detection of pituitary adenomas, various clinical signs of CD such as central obesity, moon face, hirsutism, and facial plethora are usually already present. Uncontrolled hypercortisolism is associated with metabolic, cardiovascular, and psychological disorders that result in increased mortality. Hence, the early detection and treatment of CD are not only important but mandatory. Because its clinical manifestations vary from patient to patient and are common in other obesity-related conditions, the precise diagnosis of CD can be problematic. Thus, the present set of guidelines was compiled by Korean experts in this field to assist clinicians with the screening, diagnoses, and treatment of patients with CD using currently available tests and treatment modalities.
