Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease.
10.3803/EnM.2015.30.1.105
- Author:
In Kyoung HWANG
1
;
Seon Hye KIM
;
Unjoo LEE
;
Sang Ouk CHIN
;
Sang Youl RHEE
;
Seungjoon OH
;
Jeong Taek WOO
;
Sung Woon KIM
;
Young Seol KIM
;
Suk CHON
Author Information
1. Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea. imdrjs@khu.ac.kr
- Publication Type:Case Report
- Keywords:
HLA-DQ2;
Celiac disease;
Graves' disease
- MeSH:
Asia;
Celiac Disease*;
Diagnosis;
Diarrhea;
Diet;
Diet, Gluten-Free;
Eating;
Europe;
Female;
Genes, MHC Class II;
Genetic Predisposition to Disease;
Graves Disease*;
Humans;
Leukocytes;
Middle Aged;
Prevalence;
Recurrence;
Serologic Tests;
Weight Loss
- From:Endocrinology and Metabolism
2015;30(1):105-109
- CountryRepublic of Korea
- Language:English
-
Abstract:
Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.
