Multiple Myeloma in a Patient with Acromegaly.
10.3803/EnM.2015.30.1.110
- Author:
Yu Mi KANG
1
;
Jong Han CHOI
;
Min Jung LEE
;
Ari AHN
;
Chan Jeoung PARK
;
Kiju CHANG
;
Seyoung SEO
;
Sun In HONG
;
Min Seon KIM
Author Information
1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. mskim@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Acromegaly;
Multiple myeloma;
Insulin-like growth factor I
- MeSH:
Acromegaly*;
Anemia;
Apoptosis;
Asia;
Bone Marrow Examination;
Cell Proliferation;
Consensus;
Female;
Growth Hormone;
Growth Hormone-Secreting Pituitary Adenoma;
Humans;
Insulin-Like Growth Factor I;
Middle Aged;
Mortality;
Multiple Myeloma*;
Neoplasms, Plasma Cell;
Pituitary Neoplasms;
Prognosis
- From:Endocrinology and Metabolism
2015;30(1):110-115
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acromegaly is a slowly progressing condition resulting from excess growth hormone (GH), generally caused by a GH-secreting pituitary adenoma. Cancer is the third most common cause of mortality in patients with acromegaly, and insulin-like growth factor 1 (IGF-1) is known to influence tumor formation by increasing cell proliferation and inhibiting apoptosis. Multiple myeloma (MM) is a plasma cell neoplasm, and previous studies have suggested the possible role of IGF-1 in its development of MM. However, no cases of acromegaly accompanied with MM have been reported in Asia to date. We here report the case of a 58-year-old woman with acromegaly accompanied with MM who presented with longstanding acromegalic manifestations resulting from a GH-secreting pituitary adenoma and also exhibited anemia, a reversed albumin/globulin ratio, and plasmacytosis on bone marrow examination. Because IGF-1 has been suggested to play an important role in the development and progression of MM, the patient promptly underwent surgical removal of the pituitary adenoma via a transsphenoidal approach. Since there is currently no consensus on therapeutic guidelines and suggested prognosis for MM with acromegaly, long-term follow-up of such cases is needed.
