Antineutrophil Cytoplasmic Antibodies (ANCA) in Patients with Behcet's Disease.
- Author:
Dongsik BANG
1
;
Kyeong Han YOON
;
Sang Hyun CHIN
;
Eun So LEE
;
Sungnack LEE
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
ANCA;
Behcet's disease
- MeSH:
Antibodies, Antineutrophil Cytoplasmic*;
Autoantibodies;
Cytoplasm;
Endothelial Cells;
Fluorescent Antibody Technique, Indirect;
Glomerulonephritis;
Humans;
Neutrophils;
Polyarteritis Nodosa;
Vascular System Injuries;
Vasculitis;
Wegener Granulomatosis
- From:Korean Journal of Dermatology
1998;36(4):652-656
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Antineutrophil cytoplasmic antibodies(ANCA) are autoantibodies against cytoplasmic constituents of neutrophils, and have been detected in patients with idiopathic necrotizing glomerulonephritis, crescenteric glomerulonephritis, Wegener's granulomatosis, and polyarteritis nodosa. The induction of ANCA may result in neutrophil mediated vascular injury. In Behest's disease mucosal and cutaneous lesions are often characterized by small vessel vasculitis. So the endothelial cell damage probably mediated by polymorphonuclear leukocytes has been regarded as an important pathophysiological mechanism in the disease. However, the literature has not showed the presence of ANCA in the disease, and it has been generally accepted that ANCA cannot be incriminated as a contributing factor to the abnormalities of neutrophils in Behcet's disease. OBJECTIVE: We examined the presence of ANCA in sera of 7 patients with Behest's disease. METHOD: We examined clinical and laboratory findings of 61 patients with Behest's disease, who also had cutaneous manifestations due to vascular disorders. ANCA were demonstrated in the sera of the patients by the indirect immunofluorescence method. RESULT: We found ANCA in the sera of 7 patients with complete or incomplete types of Behcet's disease. CONCLUSION: We do not yet know the meanings of the ANCA that were detected in Behest's disease. Moreover, we cannot retort against previous reports showing that ANCA were meaningless in Behest's disease in the aspects of pathophysiology. However, it is clear that ANCA can be detected in patients with Behcet's disease, so it is necessary to investigate more about ANCA in Behest's disease.
