A Case of CD3O-negative Large T-Cell Lymphoma Showing p53 and mdm-2 Expression.
- Author:
Seung Goo KANG
1
;
Young Suck RO
;
Chan Kum PARK
Author Information
1. Department of Dermatology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
CD30(Ki-1)-negative;
Large cell lymphoma;
p53;
mdm-2
- MeSH:
Antigens, CD30;
Folliculitis;
Furunculosis;
Humans;
Lymphoma;
Lymphoma, Non-Hodgkin;
Lymphoma, T-Cell*;
Mycosis Fungoides;
Phenotype;
Prognosis;
Recurrence;
Skin;
T-Lymphocytes*
- From:Korean Journal of Dermatology
1998;36(4):688-693
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Primary cutaneous large cell lymphomas of the T-cell phenotype are relatively uncommon. Previous studies have revealed the following prognostic variables: the distribution of skin lesions, a history of pre-existing mycosis fungoides, CD30(Ki-1) antigen positivity and anaplastic morphology. CD30 antigen positivity has been associated with an indolent clinical course, in contrast to CD30-negative cases. However, a recent study revealed that multicentric skin lesions confer a worse prognosis on this subgroup of patients rather than the absence of CD30 antigen. p53 immunoreactivity also has been reported to be associated with high grade non-Hodgkin's lymphoma, although it is relatively uncommon. Herein, we report a case of a patient with EBV-related, CD30-negative primary cutaneous large cell lymphoma of the T-cell phenotype showing p53 and mdm-2 expression. She was initially diagnosed as having a benign-looking deep folliculitis or furunculosis, but treated successfully with radiation therapy without recurrence up to now.
