Daily Topical Sequential Triple Therapy of Tretinoin, Betamethasone Valerate and Hydroquinone on Melasma.
- Author:
Hyoung Kyun KIM
;
Sung Kyun KIM
;
Sun Wook HWANG
- Publication Type:Original Article
- MeSH:
Betamethasone Valerate*;
Betamethasone*;
Female;
Humans;
Melanosis*;
Tretinoin*
- From:Korean Journal of Dermatology
1980;18(6):529-537
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Daily topical sequential triple therapy(tretinoin, betamethasone valerate and hydroquinone), as proposed by Kligman et al and Gano et al, has been performed on 29 Korean female patients with melasma. After 4 weeks treatment with 2% hydroquinone cream, only three of eight patients (37. 5%) showed good to excellent results. However, after 4 weeks treatment with 4% hydroquinone cream, twelve of twentyone patients (57. 1%) showed good to excellent results and its therapeutic effects appeared more rapidly than the former group. Overall, after 4 weeks treatment. 96.6% of the total group showed fair to excellent results of which 57. 7% had a good to excellent rating. The fair-com- plexioned Koreans had a better response than dark-complexioned.
