Expression and Localization of COMMD1 Proteins in Human Placentas from Women with Preeclampsia.
10.3349/ymj.2013.54.2.494
- Author:
Han Sung KWON
1
;
Seung Hwa PARK
;
Han Sung HWANG
;
In Sook SOHN
;
Soo Nyung KIM
Author Information
1. Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Seoul, Korea. 20050024@kuh.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
COMMD1;
placenta;
preeclampsia
- MeSH:
Adaptor Proteins, Signal Transducing/genetics/isolation & purification/*metabolism;
Adult;
Female;
Humans;
Placenta/*metabolism;
Pre-Eclampsia/*metabolism;
Pregnancy;
RNA, Messenger/metabolism
- From:Yonsei Medical Journal
2013;54(2):494-499
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Recently, COMMD1 has been identified as a novel interactor and regulator of hypoxia-inducible factor-1 and nuclear factor kappa B transcriptional activity. The goal of this study was to determine the difference of COMMD1 expression in the placentas of women with normal and preeclamptic (PE) pregnancies. MATERIALS AND METHODS: Immnoperoxidase and immunofluorescent staining for COMMD1 was performed on nine normal and nine severe PE placental tissues, and COMMD1 mRNA expression was quantified by quantitative reverse transcription polymerase chain reaction. RESULTS: The expression of mRNA of COMMD1 was significantly higher in the study group than in the control group. The immunoreactivity was higher especially in the syncytiotrophoblast of PE placentas than in the control group. CONCLUSION: This study demonstrated increased placental COMMD1 expression in women with severe preeclampsia compared to that found in women with normal pregnancies, and this finding might contribute to a better understanding of the pathophysiology of preeclampsia.
