A case of postoperative serotonin syndrome following the administration of fentanyl, palonosetron, and meperidine: A case report.
10.17085/apm.2015.10.4.267
- Author:
Chiu LEE
1
;
Eun Ju KIM
;
Soohyun JOE
;
Jong Seouk BAN
;
Ji Hyang LEE
;
Ji Hyun AN
Author Information
1. Department of Anesthesiology and Pain Medicine, Daegu Fatima Hospital, Daegu, Korea. kej1127@fatima.or.kr
- Publication Type:Case Report
- Keywords:
Fentanyl;
Meperidine;
Palonosetron;
Serotonin;
Serotonin syndrome
- MeSH:
Anesthesia, General;
Felodipine;
Fentanyl*;
Meperidine*;
Serotonin 5-HT3 Receptor Antagonists;
Serotonin Syndrome*;
Serotonin*
- From:Anesthesia and Pain Medicine
2015;10(4):267-270
- CountryRepublic of Korea
- Language:English
-
Abstract:
Serotonin syndrome is an unexpected adverse reaction of serotonergic medication. Some drugs used by anesthesiologists may cause serotonin syndrome. Serotonin syndrome is known to be related to 5-hydroxytryptamine 1A and 5-hydroxytryptamine 2A agonism. However, recent research has revealed evidence that 5-hydroxytryptamine 3 (5-HT3) antagonism can also play a role in serotonin syndrome. Among the 5-HT3 antagonists, palonosetron is the most highly specific. In this study, we present the first case of fentanyl- and meperidine-induced serotonin syndrome precipitated by palonosetron in general anesthesia.
