Neonatal Administration of Memantine Enhances Social Cognition in Adult Rats Subjected to Early Maternal Deprivation.
- Author:
Ezequiel URIBE
1
;
Eduardo SÁNCHEZ-MENDOZA
;
Nayadoleni NIEVES
;
Gustavo MERCHOR
Author Information
- Publication Type:Original Article
- Keywords: Schizophrenia; neuropharmacology; developing brain; glutamate; social cognition; neonatal
- MeSH: Adolescent; Adult*; Animals; Cognition*; Glutamic Acid; Humans; Interpersonal Relations; Maternal Deprivation*; Memantine*; Models, Animal; N-Methylaspartate; Neurodevelopmental Disorders; Neuropharmacology; Rats*; Schizophrenia
- From:Experimental Neurobiology 2016;25(6):328-332
- CountryRepublic of Korea
- Language:English
- Abstract: Schizophrenia is considered a neurodevelopmental disorder; however, all the available treatment options are used when the disease becomes clinically significant in adolescence or early adulthood. Using a developmental rat model of schizophrenia, we examined whether neonatal treatment with memantine, an NMDA receptor modulator, can improve schizophrenic-like symptoms in adulthood. Early maternal deprivation in rats produces deficits in social interaction behaviors in adulthood. In contrast, memantine administrated in neonatal rats subjected to early maternal deprivation significantly reduces deficits in social interaction behaviors in adulthood. These results raise the possibility that pharmacological treatment with memantine at the early developmental stage helps people with a risk to develop schizophrenic-like symptoms.
