Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBα Knock-out Mice.
- Author:
Jaehyun LEE
1
;
Hyoung Gon KO
;
Kyungjin KIM
;
Bong Kiun KAANG
Author Information
- Publication Type:rapid-communication
- Keywords: Circadian rhythm; REV-ERBα; Nociception; Inflammatory pain
- MeSH: Animals; Circadian Rhythm; Mice; Mice, Knockout*; Nociception; Phenotype
- From:Experimental Neurobiology 2016;25(6):342-346
- CountryRepublic of Korea
- Language:English
- Abstract: Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBα knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBα in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBα induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.
