Orthotopic Liver Transplantation in Dogs by Veno - venous bypass using Centrifugal Pump.
10.4097/kjae.1990.23.6.871
- Author:
Chan Woo SONG
1
;
Ping Chen WANG
;
Sung WOO
;
Kang Hee CHO
;
Kye Hyeong PAIK
;
Hyuck Sang LEE
Author Information
1. Department of Anesthesiology, College of Medicine, Inje University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Orthotopic Liver Transplantation;
Veno-venous bypass;
Centrifugal pump
- MeSH:
Academies and Institutes;
Animal Experimentation;
Animals;
Arteries;
Cardiac Output;
Constriction;
Dogs*;
Hemodynamics;
Hepatic Veins;
Korea;
Liver Diseases;
Liver Transplantation*;
Liver*;
Potassium;
Pulmonary Artery;
Pulmonary Wedge Pressure;
Reperfusion;
Thrombelastography;
Vascular Resistance;
Vena Cava, Inferior
- From:Korean Journal of Anesthesiology
1990;23(6):871-878
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The Orthotopic liver transplantation for the terminal liver diseases has been performed frequently since the introduction of new immuno-suppressive agent (cyclosporin A), technical advances in surgical skill, uae of biopump during anhephatic stage, rapid infusion system for transfusion and thromboelastography for coagulopathies were used. In Korea, only one case of orthotopic liver transplantation succeeded in 1988, but the animal experiments have been going on for many years in many institutes. Orthotopic liver transplantation in dogs using centrifugal pump (Bio-pump) were experienced and the results were analysed; 1) There were no differences in hemodynamic parameters during anhepatic stage with assistance of Biopump compared with preanhephatic stage. 2) The mean flow rate of Biopump during anhepatic stage was 0.75+/-0.09L/min, and maximun and minimum flow rate were 1.5L/min. and 0.4L/min, respectively. 3) Mean artery pressure, cardiac output and systemic vascular resistance after reperfusion of transplanted liver were significantly reduced compared with the values of before reperfusion; meanwhile, mean pulmonary artery pressure, pulmonary capillary wedge pressure and pulmonary vascular resistance were not significantly different. 4) After reperfusion of transplanted liver serum potassium level was significantly increased to 6. 07+/-1.8 mEq/L and the amount of base was significantly decrease to-12.9+/-5.9 mEq/L. By using Bio-pump the degree of hemodynamic changes could be reduced during the clamping of inferior vena cava and hepatic vein.
