Clinical Study on Antihypertensive Effect of Verapamil.
10.4070/kcj.1988.18.1.153
- Author:
Bong Kwan SEO
;
Jong Suk LEE
- Publication Type:Original Article
- Keywords:
Verapamil;
Antihypertensive effect
- MeSH:
Blood Pressure;
Calcium Channels;
Constipation;
Diuretics;
Heart Rate;
Humans;
Hypertension;
Verapamil*
- From:Korean Circulation Journal
1988;18(1):153-158
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The antihypertensive effect of verapamil, a calcium channel blocker, was studied in 12 cases of essential hypertension (mean age 49, range 24-64). After 6 weeks administration (80-160mg t.i.d.), the following results were obtained : 1) Before medication, average systolic and diastolic blood pressure was 176.3/108.6mmHg. After completion of therapy, blood presure fell significantly down to 154.8/94.2mmHg (p<0.01). 2) Heart rate decreased slightly from average 74.3 per minute prior to medication to 69.3 per minute at the end of study (p<0.01). 3) Side effects, among which constipation was most common, were mild and did not compel any patient to diacontinue therapy. In conclusion, verapamil seems to be a safe and effective first-line drug for hypertension along with diuretics or beta blockers.
