Alternative Polyadenylation in Human Diseases.
10.3803/EnM.2017.32.4.413
- Author:
Jae Woong CHANG
1
;
Hsin Sung YEH
;
Jeongsik YONG
Author Information
1. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Twin Cities College of Biological Sciences, Minneapolis, MN, USA. jyong@umn.edu
- Publication Type:Review
- Keywords:
Polyadenylation;
3′ Untranslated regions;
TOR serine-threonine kinases;
RNA 3′ end processing
- MeSH:
Eukaryota;
Gene Expression;
Humans*;
Metabolism;
Polyadenylation*;
RNA Precursors;
RNA, Messenger;
RNA-Binding Proteins;
TOR Serine-Threonine Kinases;
Transcriptome
- From:Endocrinology and Metabolism
2017;32(4):413-421
- CountryRepublic of Korea
- Language:English
-
Abstract:
Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression. Alternative polyadenylation (APA) plays an important role for cell growth, proliferation, and differentiation. In this review, we discuss the functions of APA related with various physiological conditions including cellular metabolism, mRNA processing, and protein diversity in a variety of disease models. We also discuss the molecular mechanisms underlying APA regulation, such as variations in the concentration of mRNA processing factors and RNA-binding proteins, as well as global transcriptome changes under cellular signaling pathway.
