Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients.
10.4093/dmj.2012.36.5.379
- Author:
Hye Jin YOON
1
;
Youn Zoo CHO
;
Ji Young KIM
;
Byung Joon KIM
;
Keun Young PARK
;
Gwan Pyo KOH
;
Dae Ho LEE
;
Dong Mee LIM
Author Information
1. Division of Endocrinology and Metabolism, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea. mdldm@hanmail.net
- Publication Type:Original Article
- Keywords:
Basal C-peptide;
Diabetes mellitus, type 2;
Glucagon stimulation test;
Microvascular complications;
Stimulated C-peptide
- MeSH:
C-Peptide;
Cross-Sectional Studies;
Diabetes Mellitus, Type 2;
Glucagon;
Hemoglobins;
Humans;
Injections, Intravenous;
Odds Ratio;
Plasma;
Prevalence
- From:Diabetes & Metabolism Journal
2012;36(5):379-387
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study aimed to investigate whether stimulated C-peptide is associated with microvascular complications in type 2 diabetes mellitus (DM). METHODS: A cross-sectional study was conducted in 192 type 2 diabetic patients. Plasma basal C-peptide and stimulated C-peptide were measured before and 6 minutes after intravenous injection of 1 mg glucagon. The relationship between C-peptide and microvascular complications was statistically analyzed. RESULTS: In patients with retinopathy, basal C-peptide was 1.9+/-1.2 ng/mL, and stimulated C-peptide was 2.7+/-1.6 ng/mL; values were significantly lower compared with patients without retinopathy (P=0.031 and P=0.002, respectively). In patients with nephropathy, basal C-peptide was 1.6+/-0.9 ng/mL, and stimulated C-peptide was 2.8+/-1.6 ng/mL; values were significantly lower than those recorded in patients without nephropathy (P=0.020 and P=0.026, respectively). Stimulated C-peptide level was associated with increased prevalence of microvascular complications. Age-, DM duration-, and hemoglobin A1c-adjusted odds ratios for retinopathy in stimulated C-peptide value were 4.18 (95% confidence interval [CI], 1.40 to 12.51) and 3.35 (95% CI, 1.09 to 10.25), respectively. The multiple regression analysis between nephropathy and C-peptide showed that stimulated C-peptide was statistically correlated with nephropathy (P=0.03). CONCLUSION: In patients with type 2 diabetes, the glucagon stimulation test was a relatively simple method of short duration for stimulating C-peptide response. Stimulated C-peptide values were associated with microvascular complications to a greater extent than basal C-peptides.
