Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?.
10.4093/dmj.2015.39.6.468
- Author:
Sung Hoon KIM
1
Author Information
1. Division of Endocrinology & Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea. hoonie.kim@cgh.co.kr
- Publication Type:Review
- Keywords:
Diagnosis;
Maturity-onset diabetes of the young;
Personalized treatment
- MeSH:
Diabetes Mellitus, Type 2*;
Diagnosis;
Genetic Testing;
Humans;
Korea;
Mass Screening;
Wills
- From:Diabetes & Metabolism Journal
2015;39(6):468-477
- CountryRepublic of Korea
- Language:English
-
Abstract:
Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic beta-cell function. MODY represents less than 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. At least 13 MODY subtypes with distinct genetic etiologies have been identified to date. A correct genetic diagnosis is important as it often leads to personalized treatment for those with diabetes and enables predictive genetic testing for their asymptomatic relatives. Next-generation sequencing may provide an efficient method for screening mutations in this form of diabetes as well as identifying new MODY genes. In this review, I discuss a current update on MODY in the literatures and cover the studies that have been performed in Korea.
