Comparison of basophil histamine releasability between atopic and nonatopic thmatics.
10.3346/jkms.1999.14.2.153
- Author:
Jee Woong SON
1
;
Yoon Keun KIM
;
Jae Won CHUNG
;
Sang Rok LEE
;
Sang Heon CHO
;
Kyung Up MIN
;
Young Yull KOH
;
You Young KIM
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Medical Research Center, Korea.
- Publication Type:Original Article ; Comparative Study
- Keywords:
Basophils;
Histamine release;
Asthma;
Hypersensitivity, immediate
- MeSH:
Asthma/immunology*;
Basophils/immunology*;
Basophils/drug effects;
Calcimycin/pharmacology;
Child;
Comparative Study;
Histamine Release/immunology*;
Histamine Release/drug effects;
Human;
IgE/immunology*;
IgE/blood;
Ionophores/pharmacology
- From:Journal of Korean Medical Science
1999;14(2):153-158
- CountryRepublic of Korea
- Language:English
-
Abstract:
To compare the mediator releasability between atopic and nonatopic asthmatics, we measured basophil histamine releasability (BaHR) using a calcium-ionophore A23187 and anti-IgE in 137 subjects who were treated at Seoul National University Hospital. Subjects were categorized into atopic (group AA, n=77) or nonatopic asthmatics (group NA, n=32), or normal controls (group NC, n=28). Serum total IgE levels were determined and correlation with BaHR was assessed. Anti-IgE-induced maximal BaHR in groups AA, NA, and NC was 41.0+/-3.2, 23.1+/-4.5, and 16.8+/-3.8, respectively (mean+/-SE, %). Anti-IgE-induced BaHR in group AA was significantly higher than that in groups NA and NC (p<0.05). Calcium ionophore A23187-induced maximal BaHR was 43.1+/-2.8, 40.8+/-4.4, and 50.5+/-5.2, respectively (mean+/-SE, %), and there was no significant difference among the groups. Serum total IgE level correlated significantly with anti-IgE-induced maximal BaHR (r=0.281, p<0.01) but not with that induced by calcium ionophore A23187. In conclusion, IgE receptor-related BaHR is higher in atopic asthmatics than in nonatopic asthmatics, and this increased BaHR in atopics is significantly associated with increased serum total IgE level.
